Willem Adriaan De Jongh,Teit Max Moscote Søgaard,Thomas Dan Jørgensen
申请号：
US16472414
公开号：
US20190358313A1
申请日:
2017.12.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to polypeptides suitable for protection against and diagnosis of the conditions caused by flavivirus infections. More specifically, the invention concerns subunits of the zika virus envelope glycoprotein E secreted as mature recombinantly produced proteins from eucaryotic cells, such as from insect cells. Additional viral proteins or subunits, also produced in this way, provide additional active ingredients. These protein subunits, alone or in combination including combination with additional viral-derived peptides are protective against infection by flavivirus, such as zika virus, raise antibodies useful in immunization, and are useful in diagnosis of infection by the virus.
