The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4 A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers.L'invention concerne des composés qui inhibent la protéine tyrosine phosphatase, telle que la protéine tyrosine phosphatase 4 A3 (PTP4A3). L'invention concerne également des compositions pharmaceutiques, des utilisations et des méthodes d'utilisation des composés, telles que dans le traitement de cancers.