ULTRAFEINE NANOPARTIKEL MIT FUNKTIONALISIERTER POLYORGANOSILOXAN-MATRIX, DIE METALLKOMPLEXE EINSCHLIESST ZUR VERWENDUNG IN THERAPIE UND/ODER DIAGNOSTISCHEM BILDGEBUNGSVERFAHREN
UNIVERSITE CLAUDE BERNARD - LYON 1;Institut National des Sciences Appliquées de Lyon;NANOH
发明人:
申请号：
EP19159482.9
公开号：
EP3517136A1
申请日:
2011.05.02
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The invention relates to novel biocompatible hybrid nanoparticles of very small size, particularly useful for the diagnosis and / or therapy. The object of the invention is to propose novel nanoparticles that are useful in particular as contrast agents in imaging (eg MRI ) and / or in other diagnostic techniques and / or as therapy agents, which are more efficient than the nanoparticles of the same known type and which combine at the same time a small size (for example less than 20 nm) and a strong charge rate of metals (eg rare earths), in particular to have in imaging (eg MRI) a strong enhancement and a correct response (increased relaxivity) at high frequencies.Thus, the nanoparticles according to the invention, of diameter of 1 and 20 nm each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations； a chelating graft DTPABA (diethylenetriaminepentaacetic acid dianyride) bound to the POS matrix by covalent bond -Si-C-, and present in sufficient quantity to be able to complex all the gadolinium cations； and optionally another functionalization graft Gf * linked to the POS matrix by covalent bond -Si-C- (Gf * may be derived from a hydrophilic compound (PEG), a compound comprising an active ingredient PA1； The method for obtaining these nanoparticles and their applications in imaging and therapy are also part of the invention.L'invention concerne de nouvelles nanoparticules hybrides biocompatibles de très faible taille, utiles notamment pour le diagnostic et/ou la thérapie.Le but de l'invention est de proposer de nouvelles nanoparticules qui soient utiles notamment comme agents de contraste en imagerie (e.g. IRM) et/ou dans d'autres techniques de diagnostic et/ou comme agents de thérapie, qui soient plus performantes que les nanoparticules de même type connues et qui combinent à la fois une petite taille (par exemple inférieure à 20 nm) et un fort taux de charge en métaux (e.g. terres rares), en particulier po
