Ethylenically unsaturated containing non parents of one or more, including hydrophilic units or hydrophobic units derived from a living radical polymerization of ethylenically unsaturated hydrophobic monomer or at least one ethylenically unsaturated hydrophilic monomer of 1 or more biomedical devices such as contact lenses formed from the polymerization product of a mixture comprising the amphiphilic macromonomer is disclosed.1種以上のエチレン系不飽和親水性モノマー又は1種以上のエチレン系不飽和疎水性モノマーのリビングラジカル重合から得られる親水性単位又は疎水性単位を含む1種以上のエチレン系不飽和含有非両親媒性マクロモノマーを含む混合物の重合生成物から形成されるコンタクトレンズなどのバイオメディカルデバイスが開示される。