XIAMEN ZHAOYANG BIOLOGICAL ENGINEERING CO LTD;THE THIRD INSTITUTE OF OCEANOGRAPHY,STATE OEANIC ADMINISTRATION
发明人:
YI RIUZAO,HONG BIHONG,CHEN WEIZHU,XU SHYZHEN,CHEN HUI,XIE RONWEI,HONG ZHUAN
申请号：
ZA201102010
公开号：
ZA201102010B
申请日:
2011.03.16
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
A stable freeze-dried powder preparation of tetrodotoxin and the producing method thereof. The freeze-dried powder preparation has tetrodotoxin as the main active ingredient, and comprises solubilizer, excipient and stabilizer. The said solubilizer is citricacid. The excipient is sodium chloride, mannitol or their composite. The stabilizer is dextran, trehalose or their composite. The ratio of tetrodotoxin, excipient and stabilizer is 1:150-3000:50-500 or 50-6000. Preferably, the preparation comprises lidocaine hydrochloride as function modulator. The preparation of the present invention can be used for avoiding the dependent abstinence syndrome of drugs such as opiates and cannabis.
