CZECHTIZKY, WERNGARD,GAO, ZHONGLI,HURST, WILLIAM J.,SCHWINK, LOTHAR,STENGELIN, SIEGFRIED
申请号：
MYPI 2010001300
公开号：
MY148807A
申请日:
2008.10.14
申请国别(地区):
MY
年份:
2013
代理人:
摘要：
THE PRESENT INVENTION DISCLOSES AND CLAIMS A SERIES OF SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS OF FORMULA (I). WHEREIN R, R₁, R₂, R₃, R₄ AND R₅ ARE AS DESCRIBED HEREIN. MORE SPECIFICALLY, THE COMPOUNDS OF THIS INVENTION ARE MODULATORS OF H3 RECEPTORS AND ARE, THEREFORE, USEFUL AS PHARMACEUTICAL AGENTS, ESPECIALLY IN THE TREATMENT AND/OR PREVENTION OF A VARIETY OF DISEASES MODULATED BY H3 RECEPTORS INCLUDING DISEASES ASSOCIATED WITH THE CENTRAL NERVOUS SYSTEM. ADDITIONALLY, THIS INVENTION ALSO DISCLOSES METHODS OF PREPARATION OF SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND INTERMEDIATES THEREFOR.
