G - amino butyric acid substituted, processes and Intermediates for their PreparationThat includes a Pharmaceutical Composition and its use in the treatment of diseases mediated by inhibition of NEP
These compounds have neprilisina inhibition activity.Pharmaceutical compositions comprising such Compounds Methods of using such compounds to uses of same in Therapeutics and processes and Intermediates for preparing such compounds.Claim 1: wherein is a compound of formula (1), where R1 is selected from - and - or7 nr8r9 2a is selected from - CH2OH, ch2op (- OR) (OH) 2- ch2oc and (OR) CH (NH2 or 2a R37) taken together with - CH2O - R7 to form cr18r19 - or taken along with R8 to form - CH2O - C (o) - R2B is selected from H and CH3,Or taken together to form 2A - CH2 - or - CH2 -, Z is selected between ch and N X is a heteroaryl C1 - 9 R3 is absent or is selected from h Halo rent C0 - 5 - Oh, - NH2, - C1 alkyl6. NF3 cycloalkyl - C3 - 7 rent C0 or C1 - 2 - alkyl - 6, - C (o) - Rent R20 coor21 C0 - 1 -, - C (o) - NHC (or nr22r23 or R24) = NO2 - - C = N (CH3) (Oh) phenyl optionally substituted with one or two groups SelectOften independently between Halo, - Oh, - CF3, - OCH3, CH3 - NHC (OR)And naftalenilo pyridinyl pirazinilo phenyl pirazolilo optionally substituted with Methyl tiofenilo optionally substituted with Methyl or Halo furanilo and - CH2 - morfolinilo and R3When present,Attached to a carbon Atom R4 is absent or is selected from h Oh alkyl C1 - 6 - 2 - coor35 C1 rent - ch2oc (o) CH (NH2 - och2oc R36) (o) CH (NH2 - och2oc R36) (o) CH3. Ch2op (OR) - CH2 (OH) 2CH (OH) CH2OH [CH - ch (CH3) 2] - NHC (or C1 - 6) or alkyl, phenyl or benzyl pyridinyl and optionally substituted with one or More groups selected from coor35 Halo -, -, - and - OCH3, ocf3, scf3 and R4,When present, joins an atom of carbon or nitrogen R3 and R4 are taken together to form - fenilen - or - (CH2) 1 - 3 - or - fenilen - or - Choh - CH2 - CH2 - is 0 OR 1 R5 is selected from Halo, - CH3,- CF3, and - CN b is 0 or an integer between 1 and 3 each R6 is selected independently between Halo, - Oh, - and - CH3, OCH3, - Cf3 R7 is selected from h, alkyl C1 - 8 3 - aryl - Rent C1 - C6 - 10- Hire C1 - 3 - 9 -
