Aaron K. Sato,Daniel J. Sexton,Daniel T. Dransfield,Robert Charles Ladner,Christophe Arbogast,Philippe Bussat,Hong Fan,Sudha Khurana,Karen E. Linder,Edmund R. Marinelli,Palaniappa Nanjappan,Adrian D.
申请号：
US14109508
公开号：
US09446155B2
申请日:
2013.12.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<；1 μM), and dimer and multimeric constructs comprising these polypeptides.
