A pharmaceutical composition comprising an active pharmaceutical agent and an excipient combination which acts as a diluent, disintegrant, anti-adherent or lubricant, wherein the pharmaceutical composition minimises adverse reactions to the components of the composition. In a preferred embodiment the excipient combination is rice starch and cellulose or a derivative thereof. Preferably the rice starch is pregelatinised or in the form of grains and the cellulose is crystalline or powdered. In some embodiments the composition is in the form of tablets or capsules. Preferably the compositions do not contain dyes, inks or colourings and are free from sulphites, benzoates and parabens. Carriers and drug delivery systems for the composition are also disclosed.
