The present invention relates to an isolated antibody or fragment thereof, which specifically binds to a fibroblast growth factor receptor (FGFR-3), FGFR-3(IIIb), FGFR-3(IIIc), mutant forms thereof and induces degradation of the receptor. Further embodiments include pharmaceutical compositions comprising the antibody and methods of using the antibody to treat cancer.本發明係關於一種分離之抗體或其片段,其特異性結合纖維母細胞生長因子受體(FGFR-3)、FGFR-3(IIIb)、FGFR-3(IIIc)、其突變體形式且誘發該受體降解。其他實施例包括包含該抗體之醫藥組合物,及使用該抗體治療癌症之方法。
