Novel compound having malate dehydrogenases MDH-inhibitory activity and pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;한국생명공학연구원;DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;동국대학교 산학협력단
发明人:
LEE KYEONG,이경,WON MI SUN,원미선,BAN HYUN SEUNG,반현승,KIM MINKYOUNG,김민경,KIM BO KYUNG,김보경
申请号：
KR1020180027397
公开号：
KR1020180103735A
申请日:
2018.03.08
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a compound having an inhibitory activity of at least one of MDH1 (malate dehydrogenases 1) and MDH2 (malate dehydrogenases 2), and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The present inventors have experimentally confirmed mitochondrial respiration inhibitory effect and excellent cancer cell growth inhibitory effect in the cancer cell of a compound showing MDH1 and/or MDH2 inhibitory activity. The compounds of the present invention are expected to be useful as a pharmaceutical composition for treating cancer.본 발명은 MDH1 (malate dehydrogenases 1) 및 MDH2 (malate dehydrogenases 2) 중 어느 하나 이상의 억제 활성을 나타내는 화합물 및 이를 유효성분으로 포함하는, 암 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명자들은 MDH1 및/또는 MDH2 억제 활성을 나타내는 화합물의 암세포 내 미토콘드리아 호흡 억제 효과 및 우수한 암세포 성장 억제 효과 등을 실험적으로 확인하였는바, 본 발명의 화합물은 암을 치료하기 위한 약학적 조성물로 유용하게 사용될 수 있을 것으로 기대된다.
