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COMPOSITIONS FOR ENHANCING ANTIBACTERIAL ACTIVITY OF MYELOPEROXIDASE AND WAYS OF THEIR APPLICATION
专利权人:
ЭКСОКСЕМИС; ИНК. (US)
发明人:
БЕКЕРЕЛЛЬ Софи (US),ХААГ Уилльям (US),АБРИЛ-ХОРПЕЛ Обсидиана (US),ВАЛВАНИ Шри (US)
申请号:
RU2014127120
公开号:
RU2014127120A
申请日:
2014.07.02
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A composition for inhibiting the growth of pathogenic microorganisms, including myeloperoxidase, peroxide-producing oxidase and two amino acids that act in combination, which leads to an increase in the antimicrobial activity of myeloperoxidase, where one of the two amino acids is glycine and the other of the two amino acids is selected from the group consisting of D-isoleucine, L-isoleucine, L-tyrosine and L-valine. 2. A composition according to claim 1, wherein the peroxide-producing oxidase is effective for producing from 100 pmol to 50 μmol of peroxide per ml / minute in the presence of an oxidase substrate. A composition according to claim 1, containing from 1 to 50,000 μg / ml myeloperoxidase. The composition according to any one of paragraphs. 1-3, containing from 0.1 to about 500 mM of each of the two amino acids. 5. The composition according to any one of paragraphs. 1-3, where the peroxide-producing oxidase is a glucose oxidase. 6. The composition according to any one of paragraphs. 1-3, where the composition further comprises a halide. 7. The composition of claim 6, wherein the halide is sodium chloride. A method of killing or inhibiting the growth of pathogenic microorganisms in vitro, comprising contacting the microorganisms in the presence of glucose and chloride or bromide, with a composition according to any one of claims. 1-7.9. A composition comprising a myeloperoxidase, a peroxide-producing oxidase and two amino acids, for use in the preparation of a medicament for use in treating an infection in a human or animal, where the amino acids act in combination, enhancing the antimicrobial activity of myeloperoxidase, where one of the two amino acids is glycine, and the other of the two amino acids is selected from the group consisting of D-isoleucine, L-isoleucine, L-tyrosine and L-valine. 10. Composition p1. Композиция для ингибирования роста патогенных микроорганизмов, включающая миелопероксидазу, пероксид-продуцирующую оксидазу и две аминокислоты
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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