PROBLEM TO BE SOLVED: To provide a peptide for promoting regeneration of dentin or dental pulp tissue, a composition containing the peptide, and a method for preventing or treating dentin or dental pulp disease by the composition containing the peptide. SOLUTION: A peptide in which the amino acid sequence of a peptide that increases the expression level of Dspp, Dmp1 and Nestin genes, which are odontoblast differentiation marker genes, is partially substituted, a pharmaceutical composition containing the peptide, and a drug containing the peptide. External composition, health functional food composition containing the peptide. A method for preventing or treating dentin disease or dental pulp disease, which comprises the step of administering a composition containing the peptide to a subject other than human. [Selection diagram] Fig. 9【課題】象牙質または歯髄組織の再生を促進するペプチドおよび該ペプチドを含む組成物、および該ペプチドを含む組成物による象牙質または歯髄疾患の予防または治療方法の提供。【解決手段】象牙芽細胞分化マーカー遺伝子であるＤｓｐｐ、Ｄｍｐ１、及びＮｅｓｔｉｎ遺伝子の発現レベルを増加させるペプチドのアミノ酸配列を一部置換したペプチド、該ペプチドを含む薬学的組成物、該ペプチドを含む医薬部外品組成物、該ペプチドを含む健康機能性食品組成物。該ペプチドを含む組成物をヒトを除く対象に投与する段階を含む、象牙質疾患または歯髄疾患の予防または治療方法。【選択図】図９
