The present disclosure provides antibodies that specifically bind complement pathway component C1s. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the anti-C1s antibodies; and host cells comprising the nucleic acids. The present disclosure provides compositions comprising the anti-C1s antibodies. The present disclosure provides methods of use of the anti-C1s antibodies.本發明提供特異性結合補體途徑組分C1s之抗體。本發明提供包含編碼抗C1s抗體之核苷酸序列的核酸;及包含該等核酸之宿主細胞。本發明提供包含該等抗C1s抗體之組合物。本發明提供該等抗C1s抗體之使用方法。