The invention provides novel substituted, bicyclic compounds which are useful as inhibitors of extra terminal domain BET protein function by binding to bromodomains. The pharmaceutical compositions comprising such compounds are for the prevention and treatment of diseases and conditions that are associated with bromodornain and extra terminal domain (BET) proteins.L'invention concerne des composés bicycliques substitués, qui sont utiles pour l'inhibition de protéine BET qui fonctionnent en se liant à des bromodomaines, des compositions pharmaceutiques comprenant ces composés, et l'utilisation des composés et des compositions en thérapie.