Yasmin A. Chandrasekher;Anthony W. Siadak;Wenfeng Xu;Wayne R. Kindsvogel;Margaret Dow Moore;Joyce M. Lehner;Pallavur V. Sivakumar;Stacey R. Dillon
发明人:
Wenfeng Xu,Wayne R. Kindsvogel,Yasmin A. Chandrasekher,Stacey R. Dillon,Joyce M. Lehner,Anthony W. Siadak,Pallavur V. Sivakumar,Margaret Dow Moore
申请号：
US12423699
公开号：
US08124088B2
申请日:
2009.04.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
