NOVEL HDMX INHIBITORS AND THEIR USE FOR CANCER TREATMENT

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专利权人:

Mirx Pharmaceuticals; LLC

发明人:

WALD, David,AGARWAL, Mukesh,XIA, Zhiqing,KARAN, Goutam,GUNDLURU, Mahesh

申请号：

EP15772336

公开号：

EP3125891A4

申请日:

2015.03.31

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention provides for novel acridine-like class of compounds that have demonstrated efficiency in treating cancer. The compounds of the present invention have demonstrated efficacy in binding to and antagonizing the activity of the p53 repressor, HDMX. Once administered to a cell, the compounds of the present invention bind HDMX, thereby allowing p53 to induce apoptosis of the cancerous cell. A combination of this class of compounds along with Nutlin3 provides a novel approach to treat cancers.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/