Disclosed in the present invention are antibodies that specifically recognize and antagonize human TSLP receptor, and methods of employing these antibodies to treat or ameliorate diseases or disorder mediated by TSLP signaling.本發明揭示一種特異性識別且拮抗人類TSLP受體之抗體及一種採用該等抗體治療或改善由TSLP信號傳輸所介導之疾病或病症的方法。