The present invention relates to homoserine lactone analog derivatives, preparation method and use shown in a kind of Formulas I. There is the compound bacterial community to incude adjustment effect, can use the prevention and/or treatment of related disease caused by what bacterium infection.本發明涉及一種式I所示的高絲氨酸內酯類衍生物、其製備方法和用途。該化合物具有細菌群體感應調節作用,可以用於細菌感染所致相關疾病的預防和/或治療。