Федеральное государственное бюджетное учреждение науки Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (RU)
发明人:
Никитин Максим Петрович (RU),Зелепукин Иван Владимирович (RU),Деев Сергей Михайлович (RU)
申请号：
RU2014145276
公开号：
RU2014145276A
申请日:
2014.11.11
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Agent for increasing the circulation time of the particles in the bloodstream of an organism, comprising at least an antibody against eritrotsitov.2. Agent according to claim 1, wherein said antibody -. Monoklonalnoe.3. Agent according to Claim. 1, wherein said antibody is homologous antibodies organism species, including It is a chimeric or humanized antitelom.3. Agent according to Claim. 1, which contains a number of different monoclonal antibodies against eritrotsitov.4. Agent according to Claim. 1, wherein said antibody is associated with a previously isolated from an organism or associated with erythrocyte erythrocyte donora.5. Agent according to Claim. 1, which in addition to said antibody comprises a pre-marked erythrocytes or red blood cells of the organism donora.6. Agent according to Claim. 1, the introduction of which increases the half-life of said particles is not less than 2 raza.7. Agent according to Claim. 1, the introduction of which increases the half-life of said particles is not less than 5 raz.8. Agent according to Claim. 1, wherein when administered into the bloodstream, said antibody binding to erythrocytes leads to phagocytosis by cells of the reticuloendothelial sistemy.9. Agent according to claim. 8, in which, when introduced into the bloodstream, said antibody binding to erythrocytes, resulting in phagocytosis by cells of the reticuloendothelial system, and preferably to Fc-mediated fagotsitozu.10. Agent according to Claim. 1, which when administered increases the circulation time of nanoparticles, whose size does not exceed 50 nm.11. Agent according to Claim. 1, which when administered increases the circulation time of nanoparticles larger than 50 nm.12. Agent according to Claim. 1, which when administered increases the circulation time of the particles whose size exceeds 100 nm.13. Agent according to Claim. 1, which when administered increases the circulation time of the particles whose size is1. Агент для повышения времени циркуляции
