A method for producing a recombinant protein in a plant, in particular a tobacco plant, preferably Nicotiana benthamiana, includes the following steps: a) culturing the plant aeroponically or hydroponically, preferably on mobile floats and under LED lighting b) vacuum agroinfiltration of the plant obtained in a) by agrobacteria that include a DNA fragment coding for the recombinant protein c) returning the plants to culturing after step b), under the same conditions as for step a) and d) extracting and purifying the recombinant protein from the aerial portions of the plants produced in step c).
