Devices with high-power light-emitting diodes (LEDs) for use in human and/or animal phototherapy applications are disclosed. The phototherapy device includes a number of select LEDs for emitting a desired range or ranges of wavelengths of high intensity light for use in treatment. Additionally, the phototherapy treatment includes one or more methods for providing a treatment appropriate to the condition desired to be treated. The phototherapy device provides a diversity of high power light settings, intensity levels, and selectable time intervals.