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Trazodon in hidroklorid trazodona v očiščeni obliki
专利权人:
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.
发明人:
MARCHETTI MARCELLO,IACOANGELI TOMMASO,CIOTTOLI GIOVANNI BATTISTA,BIONDI GIUSEPPE,MARCHETTI Marcello,IACOANGELI Tommaso,CIOTTOLI Giovanni Battista,BIONDI Giuseppe
申请号:
SI200831322
公开号:
SI2178850T1
申请日:
2008.07.23
申请国别(地区):
SI
年份:
2014
代理人:
摘要:
A process of production of trazodone or trazodone hydrochloride that comprises; (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.
来源网站:
中国工程科技知识中心
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