Methods and Compositions for Ex Vivo Generation of Developmentally Competent Eggs from Germ Line Cells Using Autologous Cell Systems

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专利权人:

NORTHEASTERN UNIVERSITY

发明人:

Jonathan L. TILLY,Dori C. WOODS

申请号：

US15026163

公开号：

US20160237402A1

申请日:

2014.10.07

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present technology provides for methods for the directed differentiation of multi-potent cells, female germ line stem cells, or oogonial stem cells into oocytes, granulosa cells and/or granulosa precursor cells, i.e.,“synthetic granulosa cells.” The synthetic granulosa cells are useful in methods for growth and maturation of follicles or follicle-like structures and immature oocytes. Additionally, the synthetic granulosa cells are useful in methods of increasing ovarian derived hormones and growth factors in a subject in need thereof.

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中国工程科技知识中心

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http://www.ckcest.cn/home/