"method for treating hyperproliferative dysfunction, pharmaceutical composition, use of a therapeutic combination in the manufacture of a medicament for treating cancer, article of manufacture for treating a hyperproliferative dysfunction, method for determining compounds to be used in combination for the treatment of cancer". cancer treatment and method for determining a therapeutic combination to be used for cancer treatment "
LEANNE BERRY,GAIL LEWIS PHILLIPS,MARK X. SLIWKOWSKI
申请号：
BRPI0906181
公开号：
BRPI0906181A2
申请日:
2009.03.10
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
Combinations of the antibody-drug conjugate trastuzumab-MCC-DM 1 and pertuzumab, are useful for inhibiting tumor cell growth, and for treating disorders such as cancer mediated by HER2 and KDR (VEGFR receptor 1). Methods of using such combinations for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
