Anti-microbial wound dressings, methods of making anti-microbial wound dressings and methods of treating wounds with an anti-microbial wound dressing are provided. The anti-microbial wound dressings can include a water-soluble film-forming polymeric carrier material and a water-soluble glass-encapsulated anti-microbial agent, which is embedded within the carrier and/or coated on a surface thereof. Additional active agents useful in wound care can also be embedded in and/or coated on a surface of the carrier and/or water-soluble glass.