A detachment mechanism, and methods of use, for use in delivering a medical device preferably over a guidewire are provided. The detachment mechanism includes a first and second engagement member. The members are configured to receive the guidewire and have a first end attached to the control member and the device, respectively, a second end, and a notch formed in the body to form an interlocking tooth. The notch is sized to receive the interlocking tooth of the other member. The members are interlockable to couple the medical device to the control member and to allow the guidewire to pass therethrough. The notch can be angled to permit easier detachment between the members and for better torqueability and pushability/pullability between the control member and the medical device. The members can also include a bend region configured to enhance bendability along a portion of the members.