BURGER, Matthew T.,RAMURTHY, Savithri,TAFT, Benjamin R.
申请号：
PE2017000445
公开号：
PE20171338A1
申请日:
2015.09.11
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a formula compound, wherein: R1 is h or CH3； R2 is pyridine or phenyl； X is n-och2chr3； R3 is h or Oh； R4 is 2 - (P) methyl or phosphoric acid； Z is n or Ch. it is the preferred compound: 2 - ((4 - (2-methyl-5 - (2 - (trifluoromethyl) isonicotine) phenyl) - 6-mophenopyridine-2-hydroxy) ethyl. (R) - 2 - ((4 - (2-methyl-5 - (2 - (trifluoromethyl) isonicotine) - 6 - (3-methylmorphine) pyridine-2-il) oxygen) ethyl dihydrophosphate； and so on. He also mentioned a pharmacology composer and a therapeutic approach. These compounds are acute pentachlorobenzene inhibitors, used in the treatment of breast cancer, gastrointestinal cancer and so on.Se refiere a compuestos de formula I, donde: R1 es H o CH3； R2 es piridinilo o fenilo； X e Y son N o -OCH2CHR3R4； R3 es H u OH； R4 es 2-(fosfonooxi)metil o fosfonooxi； Z es N o CH. Son compuestos preferidos: 2-((4-(2-metil-5-(2-(trifluorometil)isonicotinamido)fenil)-6-morfolinopiridin-2-il)oxi)etil dihidrogeno fosfato； (R)-2-((4-(2-metil-5-(2-(trifluorometil)isonicotinamido)fenil)-6-(3-metilmorfolino)piridin-2-il)oxi)etil dihidrogeno fosfato； entre otros. Tambien se refiere a una composicion farmaceutica y a un metodo de tratamiento. Dichos compuestos son inhibidores de quinasas Raf, siendo utiles en el tratamiento de cancer de mama, tumores gastrointestinales, entre otros
