KIM, YONG ZU,김용주,PARK, TAE KYO,박태교,WOO, SUNG HO,우성호,LEE, HYANG SOOK,이향숙,KIM, SUN YOUNG,김선영,KANG, DAE HYUCK,강대혁,CHO, JONG UN,조종운,OH, KYU MAN,오규만,JUNG, DOO HWAN,정두환,KIM, YOUNG UN,김영운,YANG, YOUNG JAE,양영재
申请号：
KR1020110025786
公开号：
KR1020120108181A
申请日:
2011.03.23
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A geldanamycin derivative with a novel guanidium group and a method for preparing the same are provided to effectively suppress the activation of HSP90 and to treat diseases related to HSP90 activation.CONSTITUTION: A geldanamycin derivative with a novel guanidium group is denoted by chemical formula 1(R-G-L-A). A composition for suppressing HSP90 activation contains: pharmacologically effective amount of a compound of chemical formula 1, pharmaceutically acceptable salt thereof, hydrate, solvate, isomer, or prodrug thereof and pharmaceutically acceptable carrier, diluent, excipient, or mixture thereof.COPYRIGHT KIPO 2013본 발명은 하기 화학식 1로 표시되는 신규한 구아니디움 기를 가지는 젤다나마이신 유도체, 그것의 약제학적으로 허용되는 염, 수화물, 용매화물, 이성질체 또는 프로드럭과, 이의 제조방법 및 이를 함유하는 의약 조성물에 관한 것이다.R-G-L-A(1)상기 식에서, R, G, L 및 A는 명세서에 정의된 바와 같다.
