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Method for the production of a solution containing high molecular weight isolated streptococcus pneumniae capsular polysaccharides, as well as a solution containing said polysaccharides
专利权人:
WYETH LLC
发明人:
JEAN HEATHER CRINEAN
申请号:
BRPI0923165
公开号:
BRPI0923165A2
申请日:
2009.12.17
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
The present invention provides improved methods for producing a solution containing high molecular weight isolated Streptococcus pneumoniae capsular polysaccharides having phosphodiester linkages between saccharide repeat units. In certain methods, CO2 is supplied to a fermentation culture of Streptococcus pneumoniae bacterial cells that produce capsular polysaccharide serotypes containing phosphodiester linkages between saccharide repeat units. Exemplary Streptococcus pneumoniae serotypes containing a phosphodiester linkage between saccharide repeat units include serotypes 6A, 6B, 19A, and 19F. Supplying CO2 to the fermentation culture includes adding bicarbonate ions to the fermentation culture, adding carbonate ions to the fermentation culture, adding mixtures of bicarbonate and carbonate ions to the fermentation culture, and overlaying the fermentation culture with CO2.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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