The present invention relates to the field of immunotherapy and more specifically to a composition comprising non-structural (NS) HCV antigens or expression vector(s) thereof to be used in combination with antiviral therapy (e.g. interferon and ribavirin standard of care (SOC) therapy) for treating an hepatitis C virus (HCV) infection. The present invention also relates to a therapeutic regimen comprising the step of administrating to a subject such an immunotherapy composition as well as a kit of parts comprising a plurality of containers and instructions for carrying out said therapeutic regimen.本發明係有關於免疫療法領域,及更詳細地係有關於一種包含非結構性(NS)HCV抗原或其表現載體的組成物,該組成物待與抗病毒療法(如干擾素與雷巴威林(ribavirin)標準照護(SOC)療法)併用於治療C型肝炎病毒(HCV)感染。本發明亦有關於一治療療程,其步驟包括對於一個體投予該種免疫療法組成物以及一試劑套組,試劑套組該包含多個容器及用於進行該治療療程之說明書。