CARTER WILLIAM A.,STRAYER DAVID,CARTER William A.,STRAYER David
申请号：
SI200931303
公开号：
SI2340307T1
申请日:
2009.10.23
申请国别(地区):
SI
年份:
2016
代理人:
摘要：
The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsRNA) having specific biological activities, which includes acting as a selective agonist for activation of the Toll-like receptor 3. Its "rugged" molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation). This structure appears to be responsible for increased efficacy of dsRNA in therapeutic applications and improved biological activity (e.g., used as an immunoregulatory agent). Medicaments, processes for their manufacture, and methods for their use are provided herein.
