Stable and uniform formulations of entecavir and preparation method thereof

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专利权人:

发明人:

申请号：

EP11161396.4

公开号：

EP2508172A1

申请日:

2011.04.06

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention relates to a process for producing pharmaceutical formulations for treating Hepatitis B virus infection, comprising entecavir and pharmaceutically acceptable excipients. The process comprises wet granulation of entecavir with pharmaceutically acceptable excipients, and is very suitable to produce low dose solid formulations with improved content uniformity and stability. The invention also pertains to low dose compositions of entecavir with improved content uniformity and stability.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/