O'MALLEY, Daniel,GLICK, Gary,GHOSH, Shomir,ROUSH, William R.,OLHAVA, Edward James
申请号：
DK18707612
公开号：
DK3510034T3
申请日:
2018.02.16
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonizes or partially agonizes) NLRP3 that are useful, e.g., for treating a condition, disease or disorder in which an increase in NLRP3 signaling may correct a deficiency in innate immune activity (e.g., a condition, disease or disorder associated with an insufficient immune response) that contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.
