There is provided a method for predicting risk of osteoporotic fracture, comprising: receiving imaging data of a computed tomography (CT) scan of a body of a patient containing at least a bone portion, the CT scan being performed with settings selected for imaging of non-osteoporosis related pathology； processing the imaging data to identify the bone portion； automatically extracting features based on the imaging data denoting the identified bone portion； computing an osteoporotic fracture predictive factor indicative of the risk of developing at least one osteoporotic fracture in the patient, or the risk of the patient having at least one severe osteoporotic fracture, based on the extracted features, the predictive factor calculated by applying a trained osteoporotic fracture classifier to the extracted features, the osteoporotic fracture classifier trained from data from a plurality of CT scans performed with settings selected for imaging non-osteoporosis related pathology； and providing the predictive factor.
