Samuel Jotham Reich;Enrico Maria Surace;Michael J. Tolentino
发明人:
Samuel Jotham Reich,Enrico Maria Surace,Michael J. Tolentino
申请号：
US13555589
公开号：
US20120308645A1
申请日:
2012.07.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.
