Disclosed are a degradable zinc base alloy implant material comprising 0.01 wt% to 14 wt% of Fe, 0 wt% to 13 wt% of functional elements and the balance of Zn by mass percentage content, and a preparation method and a use thereof. When prepared, Zn, Fe and the functional elements are homogeneously mixed and placed into a high-purity graphite crucible, and smelted same under a mixed gas atmosphere of SF 6 and CO 2 . The mechanical properties of the zinc base alloy implant material have been significantly improved, so that the implant material is easy to process and shape, and the properties of strength and plasticity, etc., meet the basic requirements of human body implant materials, such as a vascular scaffold and an orthopedic internal fixation system and the like.