CHOO, HYUN AH,추현아,KIM, YOUNG JAE,김영재,KIM, JEE YEON,김지연,YEOM, MI YOUNG,염미영
申请号：
KR1020110124122
公开号：
KR1020130058225A
申请日:
2011.11.25
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A biphenyl derivative or a pharmaceutically acceptable salt thereof is provided to ensure excellent activity to 5-HT7 serotonin receptor and to be used as a preventive and therapeutic agent for depression, migraine, anxiety, pain especially inflammatory pain and neuropathy pain, bio rhythm, sleep, smooth muscle related diseases.CONSTITUTION: A biphenyl derivative is denoted by chemical formula 2. The biphenyl derivative has a structure of chemical formula 4 or 5. A pharmaceutical composition for preventing or treating diseases contains the biphenyl derivative or a pharmaceutically acceptable salt thereof. A method for preparing the biphenyl derivative of chemical formula 2 comprises: a step of performing Suzuki coupling of aryl boronic acid of chemical formula 6 and bromobenzene aldehyde of chemical formula 7 to prepare a biphenyl aldehyde intermediate of chemical formula 8 and a step of performing reductive amination of the biphenyl aldehyde intermediate with arylpiperazine of chemical formula 9.COPYRIGHT KIPO 2013본 발명은 5-HT7 수용체에 작용하여 중추신경계 질환에 약학적 활성을 보이는 바이페닐 유도체 및 이의 약제학적으로 허용 가능한 염, 이들 화합물의 제조방법, 그리고 이들 화합물이 유효성분으로 함유된 약제조성물에 관한 것이다.
