FUCHS, TOBIAS A.,JIMENEZ-ALCAZAR, MIGUEL,GOBEL, JOSEPHINE (FORMERLY BITTERLING, JOSEPHINE),ENGLERT, HANNA
申请号：
CA3073317
公开号：
CA3073317A1
申请日:
2018.08.20
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention provides engineered DNase proteins (including DNase 1-like 3 and DNase 1) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In some aspects, the invention provides compositions and methods for preventing or treating vascular occlusion involving NETs. As demonstrated herein, NETs participate in a non-canonical mechanism for vascular occlusion, which is not dependent on fibrin or platelets.
