The present invention relates to the composition improved with what wrinkle of skin and the patches and facial mask that are improved using the composition with what wrinkle of skin, and the effective component of the composition includes: the ocean bird's nest that is handled with inonotus obliquus hypha fermentation, Sheng Mucao, Radix Angelicae Sinensis and red halloysite composite fermentation extract. Composition of the invention is made of natural materials, to skin safe, is had the effect of to prevention and improvement wrinkle of skin excellent. Also, composition of the invention effectively inhibits the expression of the directly MMP-1 and MMP-3 albumen of effect what generation wrinkle of skin, enhances the expression to I procollagen type, plays useful effect to preventing and improving wrinkle of skin. Also, effective component includes the patch and facial mask of the invention improved with what wrinkle of skin for the composition having the above advantages, and can also effectively utilize what improves wrinkle of skin.本發明涉及用於皮膚皺紋改善的組合物以及利用該組合物的用於皮膚皺紋改善的貼片和面膜，該組合物的有效成分包含：用白樺茸菌絲發酵處理的海洋燕窩、聖母草、當歸和赤石脂的複合發酵提取物。本發明的組合物由天然物質組成，對皮膚安全，對預防和改善皮膚皺紋具有優異的效果。並且，本發明的組合物有效抑制直接作用於生成皮膚皺紋的MMP‑1和MMP‑3蛋白的表達，增强對Ⅰ型前膠原的表達，對預防和改善皮膚皺紋起有效作用。並且，有效成分包含具有上述優點的組合物的本發明的用於皮膚皺紋改善的貼片和面膜，也可有效地利用於改善皮膚皺紋。
