2,3-Dihydroimidazo [1,2-c] quinazoline substituted derivatives useful in the treatment of hyperproliferative disorders and diseases associated with angiogenesis
HENTEMANN, Martin,WOOD, Jill,SCOTT, William,MICHELS, Martin,CAMPBELL, Ann-Marie,BULLION, Ann-Marie,ROWLEY, R. Bruce,REDMAN, Aniko
申请号：
ES07862580
公开号：
ES2572189T3
申请日:
2007.12.05
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound having the formula: ** Formula ** or a salt, solvate hydrate or stereoisomer thereof, in which: R1 is - (CH 5 2) n- (CHR4) - (CH2) mN (R5) (R5 ')； R2 is a heteroaryl optionally substituted with 1, 2 or 3 R6 groups； R3 is alkyl or cycloalkyl； R4 is hydrogen, hydroxy or alkoxy and R5 and R5 'can be the same or different and are independently hydrogen, alkyl, cycloalkylalkyl, or alkoxyalkyl or R5 and R5' can be taken together with the nitrogen atom to which they are attached to form a ring 3-7-membered nitrogen-containing heterocyclic optionally containing at least one additional heteroatom selected from oxygen, nitrogen or sulfur and which may be optionally substituted with 1 or more R6 'groups, or R4 and R5 may be taken together with the atoms at which are joined to form a 5-6 membered nitrogen-containing heterocyclic ring that optionally contains 1 or more nitrogen, oxygen or sulfur atoms and that may be optionally substituted with 1 or more R6 'groups； at each occurrence of R6 it may be the same or different and is independently halogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic ring, heterocyclylalkyl, alkyl-OR7, alkyl-SR7, alkyl-N ( R7) (R7), alkyl-COR7, -CN, -COOR7, -CON (R7) (R7 '), -OR7, -SR7, - N (R7) (R7') or -NR7COR7 each of which will be substituted with 1 or more R8 groups； at each occurrence of R6 'it may be the same or different and is independently alkyl, cycloalkylalkyl or alkyl-OR7； at each occurrence of R7 and R7 'they may be the same or different and are independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heterocyclic ring, heterocyclylalkyl or heteroarylalkyl； at each occurrence of R8 it is independently nitro, hydroxy, cyano, formyl, acetyl, halogen, amino, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heterocyclic ring, heterocyclylalkyl o
