Compounds for the treatment of metabotropic glutamate receptor 5 mediated disorders, and methods of use thereof

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专利权人:

大日本住友製薬株式会社

发明人:

ダグラス・バルディー,ケリー・エル・スペア,ラリー・ウェンデル・ハーディー

申请号：

JP2012503692

公开号：

JP5651681B2

申请日:

2010.04.01

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuro-muscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

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