#$%^&*AU2019201390A120190926.pdf#####- 31 Abstract A simple method for producing a clinically applicable radiopharmaceutical composition containing 1-(2,25 dihydroxymethyl-3-[1 8F]fluoropropyl)-2-nitroimidazole (['8F]DiFA) or a salt thereof as an active ingredient, is provided which includes a synthesis step of obtaining a crude product of [' 8F]DiFA from a labeling precursor compound for [' 8F]DiFA; and a purification step of 10 purifying the crude product, in which the purification step includes purifying ['F]DiFA using two or more different types of reverse phase solid phase extraction cartridges.