АУЕРБАХ Брюс Дж. (US),ХОМЭН Рейнолд (US),КРАУС Брайан (US)
申请号：
RU2012152320/15
公开号：
RU2012152320A
申请日:
2011.05.06
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of treating a condition characterized by decreased function of steroidogenic tissues, comprising: administering to a patient in need thereof an agent selected from the group consisting of LHAT, a compound that increases the activity of LHAT in plasma, an BPHE inhibitor, CDP, and any combination thereof. 2. The method according to claim 1, characterized in that the condition is characterized by adrenal insufficiency, low testosterone production or low hormone production by the ovaries. The method according to claim 2, characterized in that the condition is characterized by adrenal insufficiency. A method according to any one of claims 1, 2 or 3, characterized in that the agent is represented by native HDL. 5. The method according to any one of claims 1, 2 or 3, characterized in that the agent is a reconstituted HDL. A method according to any one of claims 1, 2 or 3, characterized in that the agent is represented by mimetic HDL. A method according to any one of claims 1, 2 or 3, characterized in that the agent is represented by LHAT. A method according to any one of claims 1, 2 or 3, characterized in that the agent is a compound that increases the activity of LHAT in plasma. The method according to any one of claims 1, 2 or 3, characterized in that the agent is an BPHE inhibitor. The method according to claim 1, characterized in that it further includes the introduction of LHAT. 11. The method according to claim 1, characterized in that it further includes the introduction of a BPHE inhibitor. The method according to any one of claims 1, 10 and 11, characterized in that the condition is represented by an acute condition selected from the group comprising a systemic inflammatory response syndrome, infection, inflammation, sepsis, trauma, burns, liver disease, kidney disease, organ transplantation, or heavy metal poisoning. 13. The method according to item 12, wherein1. Способ лечения состояния, характеризующегося пониженной функцией стероидогенных тканей, в
