BERTOLETTI, Antonio,TANOTO, Tan Anthony,KOH, Sheau Fung, Sarene,HO, Zack
申请号：
EP16916916
公开号：
EP3515935A4
申请日:
2016.09.23
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Hepatitis B Virus (HBV) antigen specific binding molecules, in particular T Cell Receptors (TCRs), TCR polypeptides and fragments thereof. The invention is also related to modified cells containing the TCRs, TCR polypeptides or fragments, pharmaceutical composition or kits including the same or methods of making or using the same as is described. In particular, the invention discloses TCRs or a fragments thereof, capable of binding to a peptide of a Hepatitis B Virus (HBV) Env polypeptide presented by an MHC class I molecule comprising an MHC class I σ-chain encoded by an HLA-Cw*08 allele.
