Rodney Kiplin Guy,Naoaki Fujii,Liang You,David M. Jablons
申请号：
US12850567
公开号：
US08211934B2
申请日:
2010.08.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula (I) or (III). The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl), inhibiting Wnt signaling.
