The invention provides for methods of treating iron deficiency and methods of reducing or eliminating the dose of erythropoiesis stimulating agent for increasing or maintaining hemoglobin levels in the target range in a subject suffering from anemia comprising administering soluble ferric pyrophosphate in an amount effective to maintain or increase Hgb levels in the subject.本發明提供治療鐵缺乏症之方法,及降低或消除用於在罹患貧血受試者中於目標範圍內增加或維持血紅素含量之紅血球生成刺激劑劑量的方法,該等方法包含以有效維持或增加該受試者中之Hgb含量之量投予可溶性焦磷酸鐵。