LANCE ALLEN PFEIFER,TIANWEI MA,NATHAN BRYAN MANTLO,LAURA FREY MICHAEL,FESE MAMBO MOKUBE,CHAHRZAD MONTROSE-RAFIZADEH
申请号：
BRPI0807949
公开号：
BRPI0807949A2
申请日:
2008.02.12
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The present invention is directed to compounds of the structural Formula: wherein: R1 is H or &mdash；C1-C3 alkyl； R2 is selected from the group consisting of &mdash；H, &mdash；C1-C4 alkyl, &mdash；C1-C3 alkyl-CF3, phenyl, and pyridinyl； and R3 is selected from the group consisting of &mdash；H, &mdash；C1-C4 alkyl, &mdash；C1-C3 alkyl-O&mdash；CH3, &mdash；CH2-cyclopropyl, CH2&mdash；C&boxH；CH2, &mdash；CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines； provided that when R1 and R2 are each H, then R3 is selected from the group consisting of &mdash；C1-C4 alkyl, &mdash；C1-C3 alkyl-O&mdash；CH3, &mdash；CH2-cyclopropyl, &mdash；CH2&mdash；C&boxH；CH2, &mdash；CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines； or stereoisomers and pharmaceutically acceptable salts thereof.
