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DERIVADOS DE PIRAZINA E A SUA UTILIZAÇÃO COMO INIBIDORES DA PROTEÍNA CINASE
专利权人:
AKINION PHARMACEUTICALS AB
发明人:
ANNIKA JENMALM JENSEN,FREDRIK LEHMANN,BJÖRN M. NILSSON,ERIK NORDLING,VENDELA PARROW
申请号:
PT09706385
公开号:
PT2252597E
申请日:
2009.01.28
申请国别(地区):
PT
年份:
2014
代理人:
摘要:
The present invention relates to compounds of the general formula (I) wherein R 1 , R 2 and R 3 are as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B-ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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