Richard DODEL,Michael Bacher,Michael Przybylski,Raluca Stefanescu,Marilena Manea
申请号：
US13079852
公开号：
US20120039897A1
申请日:
2011.04.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Isolated, monoclonal, human, anti-β-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomeric forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21-37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formulation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of Alzheimers disease and other neurodementing diseases. Methods of detecting or measuring the progression of a neurodementing disease also are provided.
